Relationships between Psychotic Symptoms and Cognitive Functions in Schizophrenic Patients

OBJECTIVES: The aim of this study was to investigate relationships between psychotic symptoms and cognitive functions in schizophrenia. METHODS: The study group was composed of 36 schizophrenic patients. Positive, negative, and disorganization symptoms were assessed using the PANSS. Verbal, visuospatial, attention, memory, and executive functions were assessed using a battery of cognitive tests. RESULTS: Correlation analysis between symptom vs. cognitive measures showed that (a) positive symptoms were significantly correlated with no cognitive measures, (b) negative symptoms were significantly correlated with all cognitive measures, and (c) disorganization symptoms were significantly correlated with executive and memory measures. Correlation analyses between symptom vs. cognitive factors showed that negative-disorganization factor is significantly correlated with executive-memory factor. CONCLUSION: Significant relationships were confined mostly to frontal symptoms vs. frontal cognitive functions. Thus, the relationships may be mediated mainly by variations in severity of frontal pathology among patients.

Effects of Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy on Intellectual and Memory Functions: 1-Year Follow-up

BACKGROUND: The aim of this study was to identify factors predicting intellectual and memory changes following anterior temporal lobectomy (ATL) for mesial temporal lobe epilepsy (TLE). METHODS: The sample consisted of 31 patients who underwent ATL for treatment of medically intractable TLE. All patients were administered intellectual and memory tests preoperatively and postoperatively. RESULTS: All statistically significant intellectual and memory changes at 1-year follow-up were in the direction of improvement. Left vs. right ATL had significantly differential effects on verbal intelligence and verbal memory, reflecting greater decline (or less improvement) following a left ATL. A later onset age of seizures, an older age at surgery, and a higher presurgical cognitive performance predicted a greater cognitive decline following an ATL. CONCLUSIONS: At 1-year after ATL, most cognitive functions showed either no significant changes or significant changes in a favorable direction. Decreased verbal functions following a left ATL was the area of greatest potential neuropsychological morbidity associated with ATL. Greater cognitive decline following ATL was predicted by later onset age of recurrent seizures, older age at time of surgery, and higher presurgical cognitive performance.

Memory Functions in Schizophrenic Patients / 신경정신의학

OBJECTIVES: The purpose of this study was to investigate memory functions in schizophrenic patients. METHODS: The participants were 45 schizophrenic patients and 27 normal controls. The Rey-Kim Memory Test (RKMT) was used as the testing instrument. RESULTS: 1) Schizophrenic patients showed a significantly lower Memory Quotient (MQ) compared with control participants. Their memory impairment was more severe relative to their intelligence impairment. 2) Memory deficits in schizophrenic patients were most pronounced in retrieval phase compared with encoding or retention phase. 3) Both verbal and visual memory were impaired in schizophrenic patients. 4) There were qualitative as well as quantitative individual differences in memory functions among schizophrenic patients. CONCLUSION: Memory impairment in schizophrenia represents a selective cognitive deficit. Its clinical presentation is similar to 'frontal amnesia' in that retrieval deficit is most pronounced.